Directly Acting Anti-HCV Drugs: Velpatasavir & Sofosbuvir

Nowadays, Chronic HCV is easily managed with medications unliked earlier. And it is possible to attained 99% of sustained viral response in its early phase with availability of newer drugs. 

Directly Acting Anti-HCV Drugs Velpatasavir Sofosbuvir


These are pangenotype drugs and can be advised to patients of HCV disease whatever may be the genotype is.

1. Velpatasavir (100mg): It is a NS5A inhibitor with more potency than the next one but with less overcoming effect to any resistance.

2. Sofosbuvir (400mg): This drug inhibits the NS5B (NS: Non-Structural protein of the Hepatitis C Virus).

Both are prescribed together with OD dosing for 12 weeks.

Popular brand name: Resof total.
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